pasted-graphic.jpg Integrin activation signaling mechanisms triggered by arrest chemokines (Frontiers topic)

integrin-activation-network.jpgSignaling network involved in integrin activation by chemokines

the-rho_rap-module-of-integrin-regulation.jpg The rho- rap-macro module of integrin affinity regulation
RED nodes = pro-adhesive role
BLUE nodes = anti-adhesive role
GREEN nodes = hypothetic role

See the updated list (09/01/2015) of signaling proteins involved in the regulation of rapid integrin activation (HGNC protein IDs).

Not all listed proteins respect the
four criteriafor integrin affinity triggering described in Front Immunol. 2012;3:127.

From Front Immunol. 2012;3:127