Integrin activation signaling mechanisms triggered by arrest chemokines (Frontiers topic)
Signaling network involved in integrin activation by chemokines
The rho- rap-macro module of integrin affinity regulationRED nodes = pro-adhesive role
BLUE nodes = anti-adhesive role
GREEN nodes = hypothetic role
See the updated list (09/01/2015) of signaling proteins involved in the regulation of rapid integrin activation (HGNC protein IDs).
Not all listed proteins respect the “four criteria” for integrin affinity triggering described in Front Immunol. 2012;3:127.
From Front Immunol. 2012;3:127
