Movement of MOG-specific T cells (blue) inside lymph nodes of immunized mice. The majority of MOG-specific T cells are not moving because involved in stable physical contacts with DCs (green).

Movement of MOG-specific T cells (blue) inside lymph nodes of immunized mice in the presence of exogenous wild-type TReg cells (red) (green: DCs). Wild-type TReg cells increase the movement of MOG-specific T cells, reducing contact time with DCs.

Neutrophils (red) migrate into the brain parenhyma of 5xFAD mice

Neutrophils (red) show strong directional movement to Amyloid-Beta rich areas (blue) in the brain parenchyma of 5xFAD mice

Neutrophil (red) adhesion in cortical vessels with Amyloid-Beta deposits (blue) of 5xFAD mice

LFA-1 integrin is necessary for neutrophil infiltration into the brain parenchyma of 5xFAD mice

Blocking LFA-1 integrin inhibits the motility of neutrophils (blue) within the brain parenchyma of 5xFAD mice