Gabriela Constantin, MD, PhD

Recipient of the ERC advanced grant IMMUNOALZHEIMER

Professor of General Pathology and Immunology
University of Verona,
Department of Medicine,
Division of General Pathology.

–––––––––––––––––––––––

Strada le Grazie 8, 37134
Verona - Italy, EU
Phone: +39-045-8027102
Fax: +39-045-802712
e-mail: gabriela.constantin@univr.it
UniVr Page: Constantin

Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease
Pietronigro E, Zenaro E, Della Bianca V, Dusi S, Terrabuio E, Iannoto G, Slanzi A, Ghasemi S, Nagarajan R, Piacentino G, Tosadori G, Rossi B & Constantin G
Sci Rep. 2019 Aug 19;9(1):12055. doi: 10.1038/s41598-019-48538-x.
PMID: 31427644

Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis.
Farinazzo A, Angiari S, Turano E, Bistaffa E, Dusi S, Ruggieri S, Bonafede R, Mariotti R, Constantin G, Bonetti B.
Sci Rep. 2018 May 10;8(1):7473. doi: 10.1038/s41598-018-25676-2.
PMID: 29748664

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3.
Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J, Xiao Y.
J Exp Med. 2018 May 7;215(5):1365-1382. doi: 10.1084/jem.20171417. Epub 2018 Apr 6.
PMID: 29626115

Functional morphology of the blood-brain barrier in health and disease.
Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G.
Acta Neuropathol. 2018 Mar;135(3):311-336. doi: 10.1007/s00401-018-1815-1. Epub 2018 Feb 6. Review.
PMID: 29411111

NETosis in Alzheimer's Disease.
Pietronigro EC, Della Bianca V, Zenaro E, Constantin G.
Front Immunol. 2017 Mar 2;8:211. doi: 10.3389/fimmu.2017.00211. eCollection 2017. Review.
PMID: 28303140

Targeting neuroinflammation in the treatment and prevention of Alzheimer's disease
Zenaro E, Constantin G.
Drugs of the Future 2017, 42; 21:42; Review

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis.
Rossi B, Constantin G.
Front Immunol. 2016 Nov 21;7:506. eCollection 2016. Review.PMID: 27917173

The blood-brain barrier in Alzheimer's disease.
Zenaro E, Piacentino G, Constantin G.
Neurobiol Dis. 2017 Nov;107:41-56. doi: 10.1016/j.nbd.2016.07.007. Epub 2016 Jul 15. Review.
PMID: 27425887

Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis.
Piermattei A, Migliara G, Di Sante G, Foti M, Hayrabedyan SB, Papagna A, Geloso MC, Corbi M, Valentini M, Sgambato A, Delogu G, Constantin G, Ria F.
Front Immunol. 2016 May 24;7:191. doi: 10.3389/fimmu.2016.00191. eCollection 2016.
PMID: 27252700

Imaging of Leukocyte Trafficking in Alzheimer's Disease.
Pietronigro E, Zenaro E, Constantin G.
Front Immunol. 2016 Feb 15;7:33. doi: 10.3389/fimmu.2016.00033. eCollection 2016. Review.
PMID: 26913031

Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Zenaro E, Pietronigro E, Bianca VD, Piacentino G, Marongiu L, Budui S, Turano E, Rossi B, Angiari S, Dusi S, Montresor A, Carlucci T, Nanì S, Tosadori G, Calciano L, Catalucci D, Berton G, Bonetti B, Constantin G.
Nat Med. 2015 Aug;21(8):880-6. doi: 10.1038/nm.3913. Epub 2015 Jul 27.
PMID: 26214837

Selectin-mediated leukocyte trafficking during the development of autoimmune disease.
Angiari S.
Autoimmun Rev. 2015 Jun 24. pii: S1568-9972(15)00137-8. doi: 10.1016/j.autrev.2015.06.006. [Epub ahead of print] Review.
PMID: 2611759

Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein.
Angiari S, Constantin G.
Trends Mol Med. 2014 Dec;20(12):675-84. doi: 10.1016/j.molmed.2014.10.003. Epub 2014 Oct 31.
PMID: 25457618

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.
Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G.
Immunity. 2014 Apr 17;40(4):542-53. doi: 10.1016/j.immuni.2014.03.004. Epub 2014 Apr 3.
PMID: 24703780

Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.
Bosticardo M, Musio S, Fontana E, Angiari S, Draghici E, Constantin G, Poliani PL, Pedotti R, Villa A.
PLoS One. 2014 Jan 23;9(1):e86942. doi: 10.1371/journal.pone.0086942. eCollection 2014.
PMID: 24466296

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
Montresor A, Bolomini-Vittori M, Toffali L, Rossi B, Constantin G, Laudanna C.
J Cell Biol. 2013 Dec 23;203(6):1003-19. doi: 10.1083/jcb.201303067.
PMID: 24368807

Selectins and their ligands as potential immunotherapeutic targets in neurological diseases.
Angiari S, Constantin G.
Immunotherapy. 2013 Nov;5(11):1207-20. doi: 10.2217/imt.13.122. Review.
PMID: 24188675

Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1.
Angiari S, Rossi B, Piccio L, Zinselmeyer BH, Budui S, Zenaro E, Della Bianca V, Bach SD, Scarpini E, Bolomini-Vittori M, Piacentino G, Dusi S, Laudanna C, Cross AH, Miller MJ, Constantin G.
J Immunol. 2013 Dec 1;191(11):5489-500. doi: 10.4049/jimmunol.1301235. Epub 2013 Oct 30.
PMID: 24174617

New players in the neurovascular unit: insights from experimental and clinical epilepsy.
Bertini G, Bramanti P, Constantin G, Pellitteri M, Radu BM, Radu M, Fabene PF.
Neurochem Int. 2013 Dec;63(7):652-9. doi: 10.1016/j.neuint.2013.08.001. Epub 2013 Aug 17. Review.
PMID: 23962437

Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model.
Marconi S, Bonaconsa M, Scambi I, Squintani GM, Rui W, Turano E, Ungaro D, D'Agostino S, Barbieri F, Angiari S, Farinazzo A, Constantin G, Del Carro U, Bonetti B, Mariotti R.
Neuroscience. 2013 Sep 17;248:333-43. doi: 10.1016/j.neuroscience.2013.05.034. Epub 2013 May 28.
PMID: 23727509

M tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2.
Nicolò C, Di Sante G, Procoli A, Migliara G, Piermattei A, Valentini M, Delogu G, Cittadini A, Constantin G, Ria F.
PLoS One. 2013;8(2):e55819. doi: 10.1371/journal.pone.0055819. Epub 2013 Feb 11.
PMID: 23409051

Leukocyte trafficking mechanisms in epilepsy.
Fabene PF, Laudanna C, Constantin G.
Mol Immunol. 2013 Aug;55(1):100-4. doi: 10.1016/j.molimm.2012.12.009. Epub 2013 Jan 23.
PMID: 23351392

Use of imaging to study leukocyte trafficking in the central nervous system.
Zenaro E, Rossi B, Angiari S, Constantin G.
Immunol Cell Biol. 2013 Apr;91(4):271-80. doi: 10.1038/icb.2012.81. Epub 2013 Jan 22. Review.
PMID: 23337699

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration.
Rougerie P, Largeteau Q, Megrelis L, Carrette F, Lejeune T, Toffali L, Rossi B, Zeghouf M, Cherfils J, Constantin G, Laudanna C, Bismuth G, Mangeney M, Delon J.
J Immunol. 2013 Jan 15;190(2):748-55. doi: 10.4049/jimmunol.1201174. Epub 2012 Dec 14.
PMID: 23241886

Chemokines and the signaling modules regulating integrin affinity.
Montresor A, Toffali L, Constantin G, Laudanna C.
Front Immunol. 2012 May 25;3:127. doi: 10.3389/fimmu.2012.00127. eCollection 2012.
PMID: 22654882

Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush.
Marconi S, Castiglione G, Turano E, Bissolotti G, Angiari S, Farinazzo A, Constantin G, Bedogni G, Bedogni A, Bonetti B.
Tissue Eng Part A. 2012 Jun;18(11-12):1264-72. doi: 10.1089/ten.TEA.2011.0491. Epub 2012 Apr 3.
PMID: 22332955

Transmigration of effector T lymphocytes: changing the rules.
Constantin G, Laudanna C.
Nat Immunol. 2011 Dec 16;13(1):15-6. doi: 10.1038/ni.2188. No abstract available.
PMID: 22179273

Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism.
Rossi B, Zenaro E, Angiari S, Ottoboni L, Bach S, Piccio L, Pietronigro EC, Scarpini E, Fusco M, Leon A, Constantin G.
J Neuroimmunol. 2011 Apr;233(1-2):97-105. doi: 10.1016/j.jneuroim.2010.12.005. Epub 2011 Jan 7.
PMID: 21216016

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions.
Rossi B, Angiari S, Zenaro E, Budui SL, Constantin G.
J Leukoc Biol. 2011 Apr;89(4):539-56. doi: 10.1189/jlb.0710432. Epub 2010 Dec 17. Review.
PMID: 21169520

Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation.
Lapilla M, Gallo B, Martinello M, Procaccini C, Costanza M, Musio S, Rossi B, Angiari S, Farina C, Steinman L, Matarese G, Constantin G, Pedotti R.
J Leukoc Biol. 2011 Feb;89(2):259-67. doi: 10.1189/jlb.0910486. Epub 2010 Nov 11.
PMID: 21071626

Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report.
Sotgiu S, Murrighile MR, Constantin G.
BMC Neurol. 2010 Sep 23;10:84. doi: 10.1186/1471-2377-10-84.
PMID: 20863362

The emerging role for chemokines in epilepsy.
Fabene PF, Bramanti P, Constantin G.
J Neuroimmunol. 2010 Jul 27;224(1-2):22-7. doi: 10.1016/j.jneuroim.2010.05.016. Epub 2010 Jun 9. Review.
PMID: 20542576

Leukocyte chemotaxis: from lysosomes to motility.
Constantin G, Laudanna C.
Nat Immunol. 2010 Jun;11(6):463-4. doi: 10.1038/ni0610-463. No abstract available.
PMID: 20485271

Regulation of leukocyte recruitment by the long pentraxin PTX3.
Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A.
Nat Immunol. 2010 Apr;11(4):328-34. doi: 10.1038/ni.1854. Epub 2010 Mar 7.
PMID: 20208538

A deadly migration.
Constantin G, Laudanna C.
Immunity. 2010 Feb 26;32(2):147-9. doi: 10.1016/j.immuni.2010.02.003.
PMID: 20189478

Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis.
Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, Anghileri E, Gini B, Bach SD, Martinello M, Bifari F, Galiè M, Turano E, Budui S, Sbarbati A, Krampera M, Bonetti B.
Stem Cells. 2009 Oct;27(10):2624-35. doi: 10.1002/stem.194.
PMID: 19676124

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module.
Bolomini-Vittori M, Montresor A, Giagulli C, Staunton D, Rossi B, Martinello M, Constantin G, Laudanna C.
Nat Immunol. 2009 Feb;10(2):185-94. doi: 10.1038/ni.1691. Epub 2009 Jan 11.
PMID: 19136961

A role for leukocyte-endothelial adhesion mechanisms in epilepsy.
Fabene PF, Navarro Mora G, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G.
Nat Med. 2008 Dec;14(12):1377-83. doi: 10.1038/nm.1878. Epub 2008 Nov 23.
PMID: 19029985

Anti-selectin therapy for the treatment of inflammatory diseases.
Rossi B, Constantin G.
Inflamm Allergy Drug Targets. 2008 Jun;7(2):85-93. Review.
PMID: 18691137

Chemokine signaling and integrin activation in lymphocyte migration into the inflamed brain.
Constantin G.
J Neuroimmunol. 2008 Jul 31;198(1-2):20-6. doi: 10.1016/j.jneuroim.2008.04.023. Epub 2008 Jun 4. Review.
PMID: 18534690

Analysis of leukocyte recruitment in synovial microcirculation by intravital microscopy.
Constantin G.
Methods Mol Med. 2007;135:333-41.
PMID: 17951669

T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.
Farini A, Meregalli M, Belicchi M, Battistelli M, Parolini D, D'Antona G, Gavina M, Ottoboni L, Constantin G, Bottinelli R, Torrente Y.
J Pathol. 2007 Oct;213(2):229-38.
PMID: 17668421

Complete repair of dystrophic skeletal muscle by mesoangioblasts with enhanced migration ability.
Galvez BG, Sampaolesi M, Brunelli S, Covarello D, Gavina M, Rossi B, Constantin G, Torrente Y, Cossu G.
J Cell Biol. 2006 Jul 17;174(2):231-43. Epub 2006 Jul 10. Erratum in: J Cell Biol. 2006 Aug 14;174(4):605. J Cell Biol. 2006 Oct 23;175(2):361. Costantin, Gabriela [corrected to Constantin, Gabriela]. J Cell Biol. 2013 Aug 19;202(4):715-6.
PMID: 16831885

VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation.
Gavina M, Belicchi M, Rossi B, Ottoboni L, Colombo F, Meregalli M, Battistelli M, Forzenigo L, Biondetti P, Pisati F, Parolini D, Farini A, Issekutz AC, Bresolin N, Rustichelli F, Constantin G, Torrente Y.
Blood. 2006 Oct 15;108(8):2857-66. Epub 2006 Jun 29.
PMID: 16809613

The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion.
Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G.
J Immunol. 2006 Jul 1;177(1):604-11.
PMID: 16785558

Absence of necrosis may help the diagnosis of hepatic metastatic neuroendocrine tumours.
Giacometti C, Constantin G, Fassina A.
Cytopathology. 2005 Oct;16(5):266-8. No abstract available.
PMID: 16181319

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.
Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G.
Nature. 2005 Jul 14;436(7048):266-71.
PMID: 16015332

Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.
Piccio L, Rossi B, Colantonio L, Grenningloh R, Gho A, Ottoboni L, Homeister JW, Scarpini E, Martinello M, Laudanna C, D'Ambrosio D, Lowe JB, Constantin G.
J Immunol. 2005 May 1;174(9):5805-13.
PMID: 15843584

PSGL-1 as a novel therapeutic target.
Constantin G.
Drug News Perspect. 2004 Nov;17(9):579-86. Review.
PMID: 15645015

Integration and independent acquisition of specialized skin- versus gut-homing and Th1 versus Th2 cytokine synthesis phenotypes in human CD4+ T cells.
Colantonio L, Rossi B, Constantin G, D'Ambrosio D.
Eur J Immunol. 2004 Sep;34(9):2419-29.
PMID: 15307174

Concurrency in leukocyte vascular recognition: developing the tools for a predictive computer model.
D'Ambrosio D, Lecca P, Constantin G, Priami C, Laudanna C.
Trends Immunol. 2004 Aug;25(8):411-6. Review. No abstract available.
PMID: 15275639

Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes.
Di Gennaro A, Carnini C, Buccellati C, Ballerio R, Zarini S, Fumagalli F, Viappiani S, Librizzi L, Hernandez A, Murphy RC, Constantin G, De Curtis M, Folco G, Sala A.
FASEB J. 2004 May;18(7):842-4. Epub 2004 Mar 4.
PMID: 15001558

A BioSpi model of lymphocyte-endothelial interactions in inflamed brain venules.
Lecca P, Priami C, Laudanna C, Constantin G.
Pac Symp Biocomput. 2004:521-32.
PMID: 14992530

RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing.
Giagulli C, Scarpini E, Ottoboni L, Narumiya S, Butcher EC, Constantin G, Laudanna C.
Immunity. 2004 Jan;20(1):25-35.
PMID: 14738762

Visualization and analysis of adhesive events in brain microvessels by using intravital microscopy.
Constantin G.
Methods Mol Biol. 2004;239:189-98. No abstract available.
PMID: 14573919

Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model.
Torrente Y, Camirand G, Pisati F, Belicchi M, Rossi B, Colombo F, El Fahime M, Caron NJ, Issekutz AC, Constantin G, Tremblay JP, Bresolin N.
J Cell Biol. 2003 Aug 4;162(3):511-20. Epub 2003 Jul 28.
PMID: 12885758

Firm adhesion of neutrophils to cerebral vascular endothelium "in vivo": a role for cys-leukotrienes.
Carnini C, Constantin G, Rossi B, De Curtis M, Folco G.
Adv Exp Med Biol. 2003;525:35-8. No abstract available.
PMID: 12751733

CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.
Battistini L, Piccio L, Rossi B, Bach S, Galgani S, Gasperini C, Ottoboni L, Ciabini D, Caramia MD, Bernardi G, Laudanna C, Scarpini E, McEver RP, Butcher EC, Borsellino G, Constantin G.
Blood. 2003 Jun 15;101(12):4775-82. Epub 2003 Feb 20.
PMID: 12595306

New models of intravital microscopy for analysis of chemokine receptor-mediated leukocyte vascular recognition.
Laudanna C, Constantin G.
J Immunol Methods. 2003 Feb;273(1-2):115-23. Review.
PMID: 12535802

Rapid leukocyte integrin activation by chemokines.
Laudanna C, Kim JY, Constantin G, Butcher E.
Immunol Rev. 2002 Aug;186:37-46. Review.
PMID: 12234360

Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors.
Piccio L, Rossi B, Scarpini E, Laudanna C, Giagulli C, Issekutz AC, Vestweber D, Butcher EC, Constantin G.
J Immunol. 2002 Feb 15;168(4):1940-9.
PMID: 11823530

Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice.
Torrente Y, Tremblay JP, Pisati F, Belicchi M, Rossi B, Sironi M, Fortunato F, El Fahime M, D'Angelo MG, Caron NJ, Constantin G, Paulin D, Scarlato G, Bresolin N.
J Cell Biol. 2001 Jan 22;152(2):335-48.
PMID: 11266450

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow.
Constantin G, Majeed M, Giagulli C, Piccio L, Kim JY, Butcher EC, Laudanna C.
Immunity. 2000 Dec;13(6):759-69.
PMID: 11163192

Induction of adhesion molecules on human schwann cells by proinflammatory cytokines, an immunofluorescence study.
Constantin G, Piccio L, Bussini S, Pizzuti A, Scarpini E, Baron P, Conti G, Pizzul S, Scarlato G.
J Neurol Sci. 1999 Nov 30;170(2):124-30.
PMID: 10561528

Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor.
Constantin G, Laudanna C, Brocke S, Butcher EC.
J Immunol. 1999 Jan 15;162(2):1144-9.
PMID: 9916745

Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis.
Constantin G, Brocke S, Izikson A, Laudanna C, Butcher EC.
Eur J Immunol. 1998 Nov;28(11):3523-9.
PMID: 9842895

Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC.
J Biol Chem. 1998 Nov 13;273(46):30306-15.
PMID: 9804792

Cultured human monocytes release proinflammatory cytokines in response to myelin basic protein.
Baron P, Constantin G, Meda L, Scarpini E, Scarlato G, Trinchieri G, Monastra G, Rossi F, Cassatella MA.
Neurosci Lett. 1998 Aug 21;252(3):151-4.
PMID: 9739983

Novel method for following lymphocyte traffic in mice using [3H]glycerol labeling.
Constantin G, Laudanna C, Butcher EC.
J Immunol Methods. 1997 Apr 11;203(1):35-44.
PMID: 9134028

Sulfatides trigger cytokine gene expression and secretion in human monocytes.
Constantin G, Laudanna C, Baron P, Berton G.
FEBS Lett. 1994 Aug 15;350(1):66-70.
PMID: 8062926

Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule.
Laudanna C, Constantin G, Baron P, Scarpini E, Scarlato G, Cabrini G, Dechecchi C, Rossi F, Cassatella MA, Berton G.
J Biol Chem. 1994 Feb 11;269(6):4021-6.
PMID: 7508438

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.
Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G.
J Exp Med. 1993 Dec 1;178(6):2207-11.
PMID: 8245792

Production of tumor necrosis factor and other proinflammatory cytokines by human mononuclear phagocytes stimulated with myelin P2 protein.
Baron P, Constantin G, D'Andrea A, Ponzin D, Scarpini E, Scarlato G, Trinchieri G, Rossi F, Cassatella MA.
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4414-8.
PMID: 7685103

Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.
Cassatella MA, Aste M, Calzetti F, Constantin G, Guasparri I, Ceska M, Rossi F.
Biochem Biophys Res Commun. 1993 Jan 29;190(2):660-7. Erratum in: Biochem Biophys Res Commun 1993 Apr 15;192(1):324.
PMID: 8381283